Hecaton Update 0.4.5 is out now.  Random Enemy Modifiers have been added.

Here are examples of the Jailor and Mortar Mods.

Update 0.4.5 Patch Notes

• Added 10 new Random Enemy Modifiers.
• Enemy Modifiers increase in frequency over time.
• Rebalanced game difficulty due to the inclusion of Random Enemy Modifiers.
• Enemy Damage Numbers to the Player has changed color to Red.
• Added an in-game indicator when a new High Rating has been achieved.
• Fixed a bug with Pentaglory Keystone that incorrectly calculated Damage.
• Altered Boss Room.
• Altered Deadbolt Gun Spire boss fight.
• Chief Engineer Kerrick's Drones can now be permanently destroyed.
• Patriot now starts with 180 Health. (was 200)
• Patriot can now Autoattack
  • Auto-Flurry Keystone has been changed to Kaminari: Flurry travels further.
• Patriot Rocket Jump Cooldown is decreased by 1 second. 
• Patriot Old Glory secondary explosions now deal 50% Damage (down from 100%) but can now trigger Relics (Accelerant, Toxic Spores, etc.).
• Sonja  Traps now deal 100% extra Damage.